If you did this well, the resulting peice would have a nice use somewhere, I'm sure.
I think it should be animated - have a bunch of guys pushing together iso blocks to make a space invader or some other stereotypical pixel thing, not a 50/50 dither pattern, people will just think "checkboard" when they see it. Also, I think adding detail to the cubes, like cracks, does detract from the overall effect. Why complicate it? It's a common downfall to clutter in unnecessary detail, don't fall into that trap. Your concept will get dilluted. Go for some less bland shading