I had a pixelling app on my psp but it was cumbersome to use with a d-pad.
DS represents the best opportunity with some great programs already available, the best stylus interface around and a whole host of other apps that could be used in conjunction. Plus it plays games for research reasons

An iPhone or iPod Touch could be worth looking into, but the accuracy of the stylus isn't as spot on as the DS, however with itunes and the SDK avaiable it may represent an easier coding process and distribution. Heck, you could even charge for it if it was good enough

Finally, I have a touch screen phone (sonyE w990i or some other) which is great for java-based apps, but I think Java is the wrong route to go down because it's slow, lags, is generally annoying - but it's easy to code for and reaches a massive range of appliances.
I'd be tempted to suggest a flash-based app. Can be run on pretty much anything (especially with flash light).
Having said that I find Flash is great for vector based uses but pixels can be a different case, and on top of that it has a nasty cheap, tacky look to it which has always put me off spending any time learning it.
So, my choice would definitely be = DS
