This is a matter of taste, but auto-rotated and imperfectly* scaled pixel art will always look sloppy to me, even if the underlying art is great. Rotation and uneven scaling destroy the clarity that pixel art can provide and just make the result look wonky. For a game with dynamic rotation and scaling, vector or high-res art looks much better than pixel art, because those distortions are not an issue there, since high-res art doesn't need each pixel to be perfect to communicate clearly.
*By "imperfect" scaling I mean scaling that's not an exact multiple, scaling where you end up with pixels of different sizes instead of them all being the same size and shape.
I'm personally not a fan of lighting like that, but I like the glimmer/animation you've got there. However, that feels more appropriate for something like fire than... floaty magic lights? The lights' animations don't suggest that they're varying in brightness, so the glimmering dynamic lights feel out of place. And since the floaty magic lights move up and down, I feel like the dynamic lights should too.
The white and red frames in the inventory screen are rather distracting and hinder the readability of the icons. The icons without frames read quite well though! I think you should simplify the frames so that the icons don't overlap them.
