I'm not entirely sure, but I recall reading about and not sure if there is a matrix difference between VA (Vertical Alignment), TN (Twisted Nematic) and IPS (In Plane Switching) LCD types, I have a vague recollection that TN monitors have horizontal sub pixels Vs Vertical.
might be wrong here but here's my assumption based on what I can recall
and I've read IPS stuff before and It's possible it doesn't even have sub pixels, actual mechanical/electronic/hardware colour blending per display pixel
so ontop of different RBG orders there is that factor too, so It further pushes the point manual adherence to 'real sub pixels' is fruitless, further adding to what I mentioned about theoretical software, it'll probably be a runtime based animation because it'd need to do the relevant sub pixel adjustments for different monitor types, as far as I know driver monitors actually effect the rendering of font too because of the sub pixel driven nature of it.
even so cons of using real sub pixels in animation is it will only work at 1x resolution, so you'd need graphics readable at 1x on most monitors, and as actual display pixels get smaller and smaller, it won't scale and will be impractical you won't even be able to perceive it unless your nose was against your display