Depth - Add more shadow and light
Style - Add more detail
In this piece it looks very flat because of the lack of shading, our eyes can only conclude that the shapes you are trying to convey are 2D rectangles with some beveled edges, get some practice on shading (either on paper or pixel) plus use of color, Hue saturation and lightness. for example, the tanks of liquid could use a darker shade nearing the center (not to dark) just to give it some variation and depth, when your shading it remeber the refraction of light with liquids, so dont just go and draw another solid block of colour in the center of the tanks, wave it about a bit.
Cant comment much on detail, it maybe that your sketch on papaer was not detailed enough and so neither is the pixel art. check your sketch again, try shading in details such as bumps and scratches maybe, a warning sticker or two, a control panel? I dont know, what ever you want.
There also seems to be various hot spots for 'jaggies' in this piece, research jaggies and why they are bad (also research banding).
EDIT: Also, for each core piece your only using like 1-3 colours, or 1-2. try 5 - 6 on a piece this big (different shades of the same colour that is).