Which color set do you think looks better, that would be more appealing in a game setting? Mostly the only change between them is that darks got darker, and the outline changed from a very dark saturated reddish to pitch black. I really like the dark saturated reddish, but the pitch black ones seem to pop more. I don't know. I'd really like some advice on this sort of coloring. A lot of my favorite artists never use full on pitch black, but I'm wondering if it has a place in games?

What Helm said is pretty much my thoughts exactly, although I'll add that the chest is confusing. The light seems to be coming from the upper left for everything else but with the chest it's almost like it's coming from the camera, lighting the top of the chest and the underside of the chest evenly even though it seems like with this chest the lid is fatter than the container, and would cast a shadow. I see that you've added small dark lines in the chest that go with the upper left lighting, but because it's only a few dark pixels and the highlight is unaffected by it, it's almost entirely unnoticeable, and even after noticing it it still doesn't read.

Other than that, if you want more indepth critique, I'd say that you'd have to post more art from the mockup since individually the girl and the ogre look great, so any further critique would have to be on how well they work with the other mockup elements, etc. Good work!

P.S. The ogre's feet make him feel just slightly like he's leaning towards isometric, would consider flattening them out.