I'm really digging the forms, so far.
However you know this isn't 320x200, the c64 res, and I do believe a big part of getting the feel for the widepixels involves those specs too, not just the wide and c64 color palette. There's only so much detail you can cram in a single screen for the c64 and that makes you reevaluate your spaces and so on. However, it could work as a vertical scroller, perhaps?
Please include slime droplets from the initial sketch to the final piece.
And you have a bit of a problem where the mandible and the eye overlap. What you have got going on there is something Ptoing told me (edit ptoing: a tangent)about once and whose name escapes me. It's where lines meet and destroy the sense of depth. It could be amended with coloring, but I sincerely suggest you re-place that eye somewhere else now that you're early on.
perhaps?