No, nothing in specific. Just imagine a color you're using in a particular piece. What I'm asking is, wherever you place that color in the piece, if you dither with it, is it a more effective dither if it conforms with the same grid over the entire piece, or does it not matter and it's more effective to dither the particular section accordingly with no regards to the dither as a whole. I use 50% dither as an example because(and correct me if I'm wrong) I consider it to be the basic form from which the other patterns (25%, 75%, etc) are built off of.