Thanks you, lachrymose!

I will go back to it someday. Now it is time to move on. To get different views onto pixel art.

By the way, here is the link to the progress-sheet: http://lakelezz.deviantart.com/art/Progress-Sheet-Last-Beating-Hearts-475418211

I tried to improve the GUI again. However I could not find a solution for the water-meter. I guess, I need to skip it.
A water bottle, can, ... could be very misleading due the second meaning of "carrying water".
I also tried a leaf. However it was somehow difficult to really feature a visible fill of water inside those little veins. While increasing the size of the veins, they leaf became too big.
If someone has an idea, I would be glad to hear about it! It would be great if you could show me something visualized (specially for the leaf idea, I am really curious), too.
Nonetheless I added some little borders between the single elements! This should be good to help "navigating" via eyes.

The table has been edited. The green stuff is the wallpaper being ripped of and laying down.
Also I edited some more mysterious black stuff on the walls, since I felt like the right wall part was so empty.

Haha, it is not like that I am new to art. However I think, we should not try to make this the absolute "perfect" piece.
But yeah, thanks! I will of course be strong. I have done so much in the last weeks. This is really amazing.

This is the piece:

Thanks you a lot, astraldata!

I will move the temp closer to the life bag again. And yes, the life bag was originally upscaled. I try to add more details though. I guess I need more on it.
The rose is representing the girl and I really like the rose and how it is representing life.
Mixed styles? Hmm, I tried to keep them all close together.. Specially the organs. The rest difficult because I felt like I need different colors. Also almost every GUI element is a first-time experience for me. Do you have a good idea for this?

Of course I want to improve in terms of animation and I will continue to work on the piece. I have to admit on the South Park style of terms of animation due the mentioned lack of frames.
The monster is meant to be much larger, he is (as you realized) not crawling but "growing" out of the human.
I am not quite sure if I understand what you mean with the arm. Why should it bother? Because it cannot collide through the chair while falling down?
I will optimize the aiming, when I get back to animating this piece.

However I will take a look at Graphics Gale.
Talking about just animating, this is the most complex animation I created before already:
Spoiler
Please do not talk about the problems that this piece is carrying. I am pretty much aware of them, haha. I just do not do huge edits once I published.
I am still learning a lot but this project taught me A LOT. The animating is just the sweet cherry at the top of it that I wanted to try.

EDIT:

Just finished some little new positioning on the GUI:


EDIT 2:

I also tried to fix the upper right part:


I somehow prefer this one. Looks more accurate.

The legs are moving, but just barely and with those table it is even more difficult.
Yes, I understand what you mean. Specially in terms of the "chunky way". I could add some more torso moving.

I will think about adding more frames to the girl. However not how she will raise the weapon. She must be carefully - that is why she will hold her weapon up all the time.
But the "aiming"-part could be interesting. However this is where question starts again: Is this more a game-mockup or just art? The GUI would stress the mockup idea.
Art would feature aiming-frames of course, but most games would not feature this. Hmmm, maybe it is time for such a feature - but that is not to be discussed here, haha.

The GUI is a case for itself. If you scroll up, you will see, that the GUI was added later on. The main reason is, the whole picture must be 16:9. At the moment there are two rows too much, but I will fix that just in the last second before publishing.
So I added a GUI, since just a pure black frame is totally boring. Merging the GUI with this scenery feels right, though.
Changing the proportion of the GUI's features is also not suitable. It would weird then.

Cleaned up GUI:


Hmm, this is a really complex piece.

There will be no lighting anymore, the idea is canceled but thanks for your ideas at this points. They might help at some other piece later on.

Hmm, I am not quite sure if I should add all of those animation stuff just for some logic. Do you really think it is one dangerous mistake of simply switching the armored hand into the foreground?
It would be weird if the monster changes his attacking hand just the logic in terms of switching.