I recently posted a sprite on another forum, and was told that by an extremely talented spriter for whom I have a great deal or respect, that "pixelart of this resolution isn't really detailed enough to quibble over". My sprite isn't even like 8 by 3 or something like that, it's 18x44, but that's not even the point. 1 pixel, isolated, I think is not detailed enough to warrant too much excitement, so therefore there must by a line. At what size are sprites meaningful?