Check the dark speech bubble thing; notice the random pixels? I doubt you did this on purpose, and I know that back before I realized it, that happened to my stuff, too. Are you using Paintshop Pro? It tries to make the image more effective, which helps a lot--on photos. When it comes to pixel art, you want each pixel to count, so, you should be concerned if the program is adding in these blemishes. You may want to find a fix to this either way, because it's not only ruining your art now, but all the potential art to come in the future.