Look, the NFL is basically a giant game of "who can survive the training room" by the time October rolls around. If you’re looking at NFL week seven predictions and just checking the box scores from September, you’re gonna lose money. Or at least look silly in your group chat.
Week 7 in the 2025 season is a mess. A beautiful, chaotic mess. We have the Indianapolis Colts sitting at a shocking 6-1, leading the AFC, while the Kansas City Chiefs are struggling at 3-3. The world is upside down. Let's get into what’s actually happening on the field, not just what the "experts" are telling you to think.
The London Headache: Rams vs. Jaguars
Wembley Stadium. 9:30 a.m. ET. Most of us will be on our second cup of coffee while the Los Angeles Rams and Jacksonville Jaguars try to figure out their jet lag.
Honestly, this game is a coin flip, but the smart money is moving toward the Rams. Why? Because the Jaguars are basically a hospital ward. They are 4-2, sure, but they’ve been scraping by. The Rams are also 4-2, but they’re getting healthy at the right time.
Keep an eye on the Puka Nacua situation. He’s been dealing with an ankle issue that has the betting lines jumping all over the place. If he plays, the Rams -3 spread looks like a gift. If he doesn't? Well, you might want to pivot to the under on 44.5 total points. London games are notoriously sluggish.
Sunday Afternoon Chaos
The 1:00 p.m. slate is where seasons go to die. Or get reborn.
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- Eagles at Vikings: Philadelphia just came off a weird loss to the Giants. They’re 5-2 and favored by 1.5, but going into Minnesota is never easy. Carson Wentz is under center for the Vikings because J.J. McCarthy is still nursing that high-ankle sprain. It’s a revenge game narrative that’s almost too perfect. Jalen Hurts needs a big day to keep the Philly media from losing their minds.
- Panthers at Jets: The Jets are 0-6. Let that sink in. They are currently a dumpster fire in a hurricane. Carolina is 3-3 and actually looks competent. The spread is only Panthers -1.5? Take it. The Jets haven't won a game against an NFC team since before some of these rookies were in college (okay, that’s an exaggeration, but they’re 0-7 SU against the NFC recently).
- Dolphins at Browns: This is the "someone has to win" game. Both teams are 1-5. It’s Mike McDaniel’s seat-is-on-fire tour. The Browns are 2.5-point favorites at home. Expect a defensive slog.
Why the Commanders are the Real Deal (No, Seriously)
If you haven't been watching the Washington Commanders, you’re missing the most entertaining team in the league. They are heading into Arlington to face the Dallas Cowboys in a game that actually matters for the NFC East.
Wait. There’s a catch.
Jayden Daniels is dealing with a low-grade hamstring injury. He’s been ruled out for the big Monday night game, but for this Week 7 Sunday clash, it's all about whether he can move. If he’s limited, the Cowboys' defense—led by a Micah Parsons who just had a 3-sack game—is going to feast.
Washington is a 2.5-point favorite on the road. That tells you everything you need to know about how much Vegas trusts the 2-3-1 Cowboys. Dallas has no Trevon Diggs (concussion) and their offensive line is held together by tape.
NFL Week Seven Predictions: The Big H2 Matchups
When you're looking for the best NFL week seven predictions, you have to look at the Monday night double-header. It's a gift from the schedule makers.
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Tampa Bay Buccaneers at Detroit Lions
The Lions are 4-2 and favored by 5.5. Detroit is just... better. The Bucs are missing Mike Evans (broken collarbone) and Chris Godwin. That is 90% of their offensive soul. Baker Mayfield is playing like an MVP candidate, but he can’t throw the ball to himself. The Lions at Ford Field are a different beast. Take Detroit and don’t look back.
Houston Texans at Seattle Seahawks
The late game. Lumen Field is going to be deafening. The Texans are 12-5 in some projections but they’ve got injury bugs too. Nico Collins has a concussion. Stefon Diggs is over in New England now (and playing great, by the way). Seattle is a 3-point favorite. This feels like a game where the home crowd forces three false starts and a crucial late turnover.
Real Talk on the Standings
The AFC West is currently being run by the Denver Broncos. Yeah, Bo Nix is actually doing it. They are 5-2 after a wild 33-32 win over the Giants where they scored 33 points in the fourth quarter. That’s not a typo.
Meanwhile, the Kansas City Chiefs are sitting at 3-3. People are panicking. "Is Mahomes done?" No. He’s just playing with a roster that has a massive hole at right guard (Trey Smith is hurt) and a defense that’s giving up too many big plays.
What the Betting Lines Aren't Telling You
The spreads are tight this week because nobody knows who is actually good. The Colts are 6-1, but are they actually the best team in the AFC? Their remaining schedule is brutal.
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- Underdog Alert: The Bengals are 5.5-point underdogs against the Steelers. Pittsburgh’s defense is giving up way too many yards (over 370 a game). Joe Burrow usually wakes up right around this time of year. Don’t be surprised if Cincy covers or wins outright.
- The "Stay Away" Game: Raiders at Chiefs. The spread is 11.5. Kansas City should win, but they haven't been covering big numbers lately. Maxx Crosby is banged up for the Raiders, which helps KC, but double-digit spreads in divisional games are bait.
Actionable Insights for Your Picks
If you're making moves this weekend, keep these factors in your back pocket. They matter way more than the "vibes."
- Injury Reports are King: Don't bet on the Bucs without realizing their WR room is empty. Don't bet on the Commanders if Jayden Daniels isn't 100%.
- The London Factor: Fade the favorites in London unless they have a dominant run game. The travel usually kills the passing timing.
- Home Field at Mile High: The Broncos are 5-2 for a reason. That altitude and their defense (statistically the best in the NFL right now) make them a nightmare for visiting teams.
- The "Revenge" Narrative: Carson Wentz against the Eagles. It’s a story as old as time. He’ll either throw 4 touchdowns or 4 interceptions. There is no in-between.
Keep a close eye on the late-breaking injury news regarding Josh Jacobs (Packers) and Sauce Gardner (Jets). Those two alone can swing their respective games by three or four points.
Monitor the weather in Chicago for the Saints-Bears game. If it’s as wet and slick as predicted, the "under" becomes the best bet of the weekend. High-scoring offenses crumble on grass that feels like a slip-and-slide.
Get your picks in early, but leave yourself room to pivot if a star player is ruled out 90 minutes before kickoff.