NFL Week 7 is officially here, and honestly, the board looks like a total mess. If you've been following the 2025 season so far, you know that parity isn't just a buzzword this year; it's a headache for anyone trying to put money down. We’ve got teams like the Steelers looking like world-beaters under Mike Tomlin's spite-fueled energy, while the Eagles are basically in a free-fall that feels eerily like their late-2023 collapse.
Every week someone asks for the lock of the century. There are no locks. Not this year. The Buffalo Bills and Baltimore Ravens are resting on their byes, which leaves us with a 15-game slate that includes everything from a London breakfast game to a double-header on Monday night. Let's get into the weeds of these NFL week 7 score predictions and see where the actual value is hiding.
The London Special and Early Sunday Chaos
The Sunday morning tradition continues at Wembley Stadium with the Los Angeles Rams taking on the Jacksonville Jaguars. It’s funny because, before the season, people thought this would be a blowout. Instead, both teams are sitting at 4-2. The Rams have the 3rd best defense in the league, allowing just 18.3 points per game. Meanwhile, the Jaguars secondary is giving up passing yards like they're handing out flyers.
Prediction: Rams 22, Jaguars 20. It’s going to be close because London games are always a bit clunky. Expect Sean McVay to lean on the ground game to keep Trevor Lawrence off the field.
Mike Vrabel’s Revenge in Music City
The New England Patriots heading into Tennessee to play the Titans is the definition of a "narrative game." Mike Vrabel was fired by the Titans not that long ago, and now he’s got the Patriots sitting at 4-2 with Drake Maye looking like a legit franchise cornerstone. The Titans? They’re a disaster. They’ve allowed 25 sacks—the most in the league—and Cam Ward is basically running for his life on every snap.
Prediction: Patriots 28, Titans 13.
New England is 3-0 against the spread on the road this year. Tennessee is 0-2 at home. You do the math.
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NFL Week 7 Score Predictions for the Afternoon Slate
This is where things get weird. The Washington Commanders and Dallas Cowboys are meeting in Arlington, and the odds have been bouncing around like crazy. Washington is actually favored by 1.5 points on the road. Think about that. The Cowboys have a 2-3-1 record and the vibes in Big D are reaching a toxic level.
Prediction: Commanders 30, Cowboys 24.
Jayden Daniels is playing like a seasoned vet, while the Cowboys' defense looks like they forgot how to tackle. If the Commanders don't turn the ball over three times (like they did against the Bears), they should walk away with this one.
The Mile High Reality Check
The New York Giants are feeling themselves after a decent start, but going into Denver is a nightmare. The Broncos' defense is elite. They’re 2nd in the league in points allowed (15.8) and they lead the NFL in sacks. Jaxson Dart has been a fun story for the Giants, but playing at altitude against a pass rush that doesn't quit? That’s a tall order.
Prediction: Broncos 24, Giants 16.
Denver’s offense isn't great, but they don't have to be when the defense is putting up historical numbers.
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Sunday Night and the Monday Night Double-Header
The San Francisco 49ers host the Atlanta Falcons on Sunday Night Football. The Niners have been decimated by injuries. Brock Purdy’s turf toe is the big question mark, but even a banged-up San Fran team is tough at home. The Falcons are coming off a massive upset over the Bills, but they have to travel across the country on a short week.
Prediction: 49ers 25, Falcons 16.
Kyle Shanahan usually finds a way to scheme around missing pieces, especially when Christian McCaffrey is available to handle 25 touches.
Monday Night’s Main Events
We get two games on Monday. First, the Tampa Bay Buccaneers (5-1) visit the Detroit Lions (4-2). This has "track meet" written all over it. Both teams can score in bunches, and the Lions are 5.5-point favorites at Ford Field.
Prediction: Lions 28, Buccaneers 27.
In the late game, the Houston Texans go to Seattle. The Texans have the #1 ranked defense in terms of points allowed. That’s scary. However, Lumen Field is a house of horrors for young quarterbacks, and Geno Smith—wait, actually Sam Darnold has been the guy there lately and he’s been surprisingly efficient.
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Prediction: Seahawks 22, Texans 18.
What We Can Learn From the Betting Lines
If you look at the NFL week 7 score predictions from the sharps, you’ll notice a lot of love for underdogs this week. The Saints are +5.5 against the Bears, which feels like a trap game for Chicago. The Colts are +1.5 against the Chargers, and with Jonathan Taylor running behind a top-5 offensive line, they could easily pull the upset.
Don't ignore the Over/Under on the Dolphins vs. Browns game. It’s set at 35.5. That is basement-level low. Both teams are 1-5 and neither can move the ball. It’s going to be an ugly, defensive slog.
Actionable Strategy for Week 7
- Watch the injury reports for the 49ers: If Purdy and Kittle are both out, that 49ers-Falcons line is going to move significantly.
- Fade the Titans offensive line: They cannot protect the quarterback. Until they prove otherwise, betting against them—or taking the "Under" on their team total—is a solid play.
- Trust the Broncos defense at home: They are making even good quarterbacks look like rookies.
- Monitor the Commanders' turnovers: They are moving the ball at will, but self-inflicted wounds are the only thing keeping their games close.
The 2025 season is proving that no lead is safe and no favorite is a sure thing. Week 7 is likely to provide a few more "how did that happen?" moments before the Tuesday morning recaps hit.
Check the weather for the Cleveland and Chicago games on Sunday morning. High winds at Soldier Field or Huntington Bank Field can turn a high-scoring game into a kicker's nightmare in seconds. Focus on the trenches in those matchups; teams that can run the ball consistently, like the Colts and Lions, are much safer bets than those relying on deep-ball precision in October weather. Regardless of who you're backing, keep your unit sizes small this week because the volatility is at an all-time high.