You’ve probably looked at your fantasy roster and realized half your starters are missing. That’s because the nfl week 10 schedule is basically the "Landmine Week" for football fans. We are right in the thick of the 2025 season. It’s November. The weather is starting to turn nasty in places like Green Bay and Chicago, and the playoff picture is about as clear as a foggy morning in London.
Honestly, Week 10 is where seasons go to die or find new life. We have heavy hitters like the Kansas City Chiefs and Dallas Cowboys sitting at home on their couches, leaving a massive void in the TV broadcast slate. If you aren’t paying attention to the specific timing of these games, you’re going to miss the fact that we’re starting the action before most people in the U.S. even have their coffee ready.
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The Berlin Takeover and Morning Madness
We aren't just staying stateside this week. The nfl week 10 schedule actually kicks off its Sunday slate in Berlin, Germany. The Atlanta Falcons are taking on the Indianapolis Colts at the Olympic Stadium. This is a 9:30 a.m. ET kickoff. If you're on the West Coast, that’s 6:30 a.m. Better set an alarm or just stay up late.
The Colts have been surprisingly balanced this year, but the Falcons are a total enigma. One week they look like world-beaters, and the next they can't find the end zone with a map. It’s the kind of game that usually rewards the team that adjusts to the jet lag faster.
After the international breakfast game, we move into the standard 1:00 p.m. ET window. This is where the bulk of the action lives. You've got divisional rivalries that feel a bit more desperate than usual. Take the Buffalo Bills heading down to Miami to face the Dolphins. It’s always a track meet when these two play, and with Buffalo trying to keep their lead in the AFC East, the stakes are massive.
Key Matchups to Watch
- Detroit Lions at Washington Commanders (4:25 p.m. ET): This is arguably the game of the afternoon. The Lions have one of the most balanced attacks in the league, but Washington's defense has been surprisingly stout under the new regime.
- Los Angeles Rams at San Francisco 49ers (4:25 p.m. ET): A classic NFC West slugfest. The Rams managed to pull off a 42-26 victory here, which actually shocked a lot of people who had written them off early in the season.
- Baltimore Ravens at Minnesota Vikings (1:00 p.m. ET): Baltimore's pass rush against Minnesota's young core. It’s a contrast in styles that usually ends in a defensive struggle.
Primetime Heavyweights
The nfl week 10 schedule saves some of the best drama for when the sun goes down. Sunday Night Football features the Pittsburgh Steelers traveling west to face the Los Angeles Chargers. We're talking 8:20 p.m. ET on NBC. Aaron Rodgers leading a 5-3 Steelers team into SoFi Stadium is a storyline nobody predicted at the start of the year. The Chargers are sitting at 6-3, so this is essentially an early playoff game for AFC seeding.
Then there’s Monday night.
The Philadelphia Eagles at the Green Bay Packers. Lambeau Field in November is holy ground for football fans. The Eagles are coming off a bye week, which means they are fresh and likely have a few new wrinkles in their playbook. Green Bay, meanwhile, is trying to bounce back after a rough outing where Jordan Love struggled to find his rhythm. It’s a 8:15 p.m. ET kickoff on ABC and ESPN.
Who is Missing?
You need to account for the bye weeks. This is non-negotiable for fantasy players and bettors alike. In Week 10, four teams are off:
- Kansas City Chiefs
- Cincinnati Bengals
- Dallas Cowboys
- Tennessee Titans
Losing the Chiefs and Bengals in the same week is a massive blow to the league’s overall star power for these few days. It means more eyes on teams like the Jets and Browns, who are fighting for scraps at the bottom of the standings but still provide plenty of betting drama.
Making the Most of the Slate
Don't just look at the home team and assume they have the advantage. For example, the New England Patriots actually traveled to Tampa Bay and pulled off a 28-23 win as underdogs. The "experts" often miss these mid-season shifts where struggling teams finally find their identity.
If you're planning your viewing, prioritize the 4:25 p.m. window. That’s where the high-leverage NFC games are clustered this week. Also, keep an eye on the weather reports for the Chicago vs. New York Giants game. Soldier Field in November can turn a high-flying offense into a grinding run game in a matter of minutes.
To stay ahead of the curve, verify your local listings for the 1:00 p.m. games, as CBS and FOX split these based on your region. If you have NFL RedZone, this is the week to use it, especially with the volume of games happening simultaneously in the early window. Check your fantasy lineups for those four bye-week teams and make your waiver wire moves before the Thursday night game between the Raiders and Broncos kicks off.