You’ve seen her face. Maybe it was while you were flipping through channels and caught a glimpse of a forensic scientist talking to a German Shepherd. Or maybe you remember a ruthless, high-stakes politician in a spaceship.
Mayko Nguyen is everywhere.
Honestly, she is one of those actors who just fits into any world she’s dropped into. From the gritty bio-labs of ReGenesis to the snowy streets of St. John’s in Hudson & Rex, Nguyen has spent the last two decades becoming a pillar of Canadian entertainment. But if you think she's just "that one girl from that one show," you're missing the bigger picture.
The Hudson & Rex Phenomenon (And Why We Can’t Stop Watching)
Let’s talk about the elephant—or rather, the dog—in the room. If you search for Mayko Nguyen movies and tv shows, the first thing that pops up is Hudson & Rex.
Playing Dr. Sarah Truong isn't just about looking into microscopes. Sarah is the heart of the team. Since 2019, Nguyen has brought a certain groundedness to a show that, on paper, sounds a bit kitschy. A cop and a dog? It’s been done. But Sarah Truong makes it feel real.
She isn't just a "lab geek." In recent seasons, she's moved into a mobile unit role. She’s out in the field, sometimes holding a gun, always being the smartest person in the room. Nguyen has mentioned in interviews that moving to Newfoundland for the show was a huge shift. It was cold. It was wet. But that authenticity bleeds into the performance.
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Hudson & Rex is currently one of the most successful Canadian exports in recent memory. It’s huge in Europe. It’s huge in the UK. And a big reason for that is the chemistry between Nguyen and John Reardon.
From Mayko Tran to Delle Seyah: The Range is Wild
Before she was solving crimes with a canine, Nguyen was breaking hearts and minds in ReGenesis. This was her big break.
Playing Mayko Tran—a bioinformatics expert—she wasn't just a supporting character. She was the anchor. If you haven’t seen the "breakdown" episodes of ReGenesis, go find them. The writers put her character through the ringer. It’s intense stuff.
Then, she did a total 180.
Enter Killjoys. If you want to see Nguyen play someone truly, deliciously "bad," this is it. Delle Seyah Kendry is a masterpiece of a character. She’s cold, manipulative, and incredibly stylish.
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"She’s generally quite contained. To get to the point she loses it a bit... was a lot of fun," Nguyen once said about the character's evolution.
Watching her go from the vulnerable Mayko Tran to the shark-like Delle Seyah is a masterclass in range. One minute she’s a scientist you want to protect, the next she’s a space-politician you’re terrified of.
The Movies You Might Have Missed
While her TV work is the heavy hitter, Mayko Nguyen’s movie credits are surprisingly diverse. She doesn't just stick to the safe stuff.
- Below Her Mouth (2016): This was a bold one. It’s an uninhibited, all-female-crew drama that didn't shy away from anything. Nguyen played Joslyn, and while it was a supporting role, she added a layer of realism to a very heightened, passionate story.
- The Righteous (2021): A psychological thriller that feels like a fever dream. If you like "weird" cinema, this is the one to track down.
- Simulant (2023): Back to her sci-fi roots. She plays Michiko Higashi in a world where androids are basically indistinguishable from people. It’s sleek, it’s moody, and it proves she still has that sci-fi "it" factor.
- Going the Distance (2004): A total throwback. Before the serious dramas, she was doing Canadian teen comedies. Everyone has to start somewhere, right?
Why She Matters in 2026
The industry is changing. We see it every day. But actors like Mayko Nguyen are the reason people still tune into "appointment television."
She has been nominated for multiple Canadian Screen Awards (including back-to-back Lead Performer nods in 2023 and 2024). People are finally starting to realize she isn't just a reliable guest star—she’s a leading lady.
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There’s a new project on the horizon called Begin Again. Details are still a bit hush-hush, but she’s playing a character named Denise. If her track record is any indication, it’s going to be something that makes us look at her in a completely different way.
The "Everywhere" Factor: A Quick List of Guest Spots
Sometimes you’re watching a show and you go, "Wait, is that...?" Yeah, it usually is. Her guest-star resume is like a checklist of "Greatest Canadian Hits":
- Rookie Blue: She played Sue Tran for three seasons.
- Slasher: She was in the first season (The Executioner) as Alison Sutherland.
- Titans: She showed up as Adeline Kane.
- Being Erica: She played Antigone in a couple of episodes.
- Cracked: She was Detective Liz Liette.
Basically, if a show was filmed in Toronto or Vancouver between 2005 and 2015, Mayko Nguyen was probably in it.
What to Watch First?
If you're new to her work, don't just dive into the middle.
Start with Killjoys if you love world-building and complex villains. If you want something cozy and comforting to watch on a Sunday afternoon, Hudson & Rex is the obvious choice. But if you want to see the raw talent that started it all, find the old DVDs of ReGenesis. It holds up.
Next Steps for Fans:
- Check out the 2025/2026 season of Hudson & Rex to see how the "Mobile Unit" dynamic evolves.
- Track down The Righteous on streaming for a look at her work in the indie thriller space.
- Keep an eye out for her voice work in Unicorn Academy on Netflix—it’s a side of her you haven’t heard before.