I was thinking about something completely different when I wondered this, but it's actually worth talking about in terms of art.
How much of what I "know" to be real actually exists in a concrete sense, and how much of what I "know" is subjective perception?
Example: The time on the microwave is blurry and unreadable to me from this side of the room, so I ask my room mate for the time. He tells me that it's 5:52. I glance at the microwave again and see that it reads 5:52.
It ought to be a pressing issue, artistically, to discover just how much of what I perceive exists actually and how much my brain fills in, don't you think? After all, what I believe to be real is the basis of what I communicate with my art, and if what I believe to be real is different from the way things actually are, my message is going to lose a certain amount of validity.
From this, I got to thinking: I think that a talented artist could present the world to a viewer in a way that agrees with the way that the viewer perceives the world. Or a more talented still artist could exploit this "relate-ablilty" as another artistic element.