You are right eishiya, form will also be a huge factor, organic Vs artificial rectangular blocks. It's meant to be made of vessels, tubes, some kind of placenta. Pretty close to the War of the World stuff I guess.
Right now I face a dilemma: I'm really happy about the bricks ,specially the big ones, but the palette is to broad. I've lost a bit of the simplicity of my characters, only tow shades per colour, no AA. The same is true of the overall noise produce by so many lone bricks with individual shading, I should go back to a more simple aesthetics, with more freedom on abstraction.
Truth is, the current standard of quality will be detrimental to my project, assets will take to much time to produce, and be to complex to fit the mood I aim for. So it's time to tone it down a bit. It's the day's goal, I will post something soon.
@MysteryMeat
Yeah, I think overall the stone will remain in the blue/green area, and the organic stuff, monsters and mucus, should be in the red/orange.
[EDIT]
New:
Old for comparison:
I have heavy handedly edited my assembly test to make some adjustments on the palette and the fading of blocks. I limited the palette, removed a lot of pixel clusters, and made the shape of the blocks fade in the darkness. Overall it's much lighter, more contrasted, background tiles would be easily readable as background. It's also a lot more saturated. It's a dirty edit so a lot of stuff is to be perfected, I plan on having a lot more flat single coloured surfaces with fewer details, to have contrast in detail amount too. The squint test also show that walk-able path is easier to distinguish.
What do you think?