Yeah, I want to think of this one as more of an art piece that stands alone rather than one specifically made for use in a game. Just as there is pixel-art that is not meant for a game, there is also 3d art that is not meant for games.
However, due to the nature of the style, it kind of stirs up feelings of game-related stuff.
So, yeah- if it is something that could be a new sort of art, it might serve better to look at it from beyond the perspective of a game.
I've wanted to use Pepakura Designer to flatten the models built with Crocotile3d and then print them out and create physical models. I think it would be cool, and would also make it more of an art-form.
I was imagining creating a whole gallery using physical models in this style because it would be visually striking and different from the norm. I want to find a good technique for doing so that results in physical models that are sturdy and well made so that they don't look like just some printed paper.
I have some ideas on how I would do it, but doing it is the time-consuming part.

edit: I suppose the smart thing to do would be to create a box or something simple and figure out the technique that works best, and then work up to a larger scale.