Ages ago I talked about studying clusters in animation. I just never found the right examples to really pursue it. I just noticed a great example in
this thread by The Phinx. What I want to do is a cluster study similar to
this one where we study a single sprite and do edits.
The goal of the exercise is to identify clusters and look how they move/change in time. You will notice that larger clusters tend to behave organically, while smaller clusters, especially single pixel, stay very rigid (look at the speculars on the arm for example). If the small clusters where to move/change too much, you'd just get animated noise that doesn't convey motion very well.

The sprite itself is really well made. It has some great clusters going on and the animation works really well (apart from some the legs being a bit noodly perhaps). At the same time, there's some areas that can be improved. The head clusters work well when paused, but in motion, they seem to behave a bit erratically. The highlight on the left leg (HIS right) seems to be really jumpy and I feel this is a great cluster to try and make behave. Also, the lower part of that leg seems to have a lot of banding that you can fix. The abdominal region has some bad banding that needs to be fixed, this can be done in multiple ways I feel. You can simplify the cluster, try to simply eliminate the banding or experiment with subpixel animation to try and make that work. I'm sure there's other solutions

.
So yeah, basically the gist of the exercise is: How can we adjust modern pixel techniques like clusters and banding awareness to animation? Secondary to this, there's also room to discuss other high-level pixel techniques concerning animation, like subpixel animations.
Like the previous cluster study, the idea is to keep the spirit of the sprite, not to radically alter it. Also remember that The Phinx graciously allowed me to use his sprite, which seems to be a character he conceived, so extra respect is due.
I'll post my own findings after a few people have had the chance to study. I'll probably show off a few details of things I picked up over the years concerning pixels in motion. Have fun!