Right now chrome is the only browser that supports Midi devices.
You still have to activate it by typing this into the url bar though chrome://flags/#enable-web-midi
Yes I tested Gimps Midi integration some time ago and you can actually change colors/opacity mid-stroke.
There is one flaw with it though. You can't for example assign just one fader/knob to a property like brush size, you have to assign TWO.
One fader to decrease the brushsize and one to increase it. So if you want to change all three color channels, you need 6 fader. That isn't possible with one hand anymore, so it defeats the purpose of single-handedly changing the colors.
I didn't think about the keyboard layout, I'm using a german layout.
I changed the shortcuts so they should work with most international keyboards:
'x' and 'c' to change brightness
's' and 'd' to change saturation
'w' and 'e' to change hue
AleyHW's pixel.tools is nice! I should ask him so integrate Midi support!

Thanks for your feedback, I'll take a look at the fill tool icon and try to improve it.
cheers
Heinz