Personally I'd really love to make a HD game - it's much harder to get right though for sure (not to mention more work).
As much as I love pixels they're not perfect for everything. We have to be honest - marketing wise, there's an ever widening age-group behind us that didn't grow up with it, and potentially doesn't get it. Not going to stop us, of course, but sometimes it feels like it's getting increasingly niche and self-indulgent. (I hope this isn't too inflammatory, I certainly don't want to discourage any of us dedicating a lot of time perfecting the art, all I mean is it's not all there is to know).
(2D) HD games are still relatively virgin territory, there's plenty that hasn't been done or fully explored. Style wise you can look exactly like any saturday morning cartoon, classical painting, modern art, collage, anime, claymation - whatever your personal style it can be right there with no disguise. I find that pretty exciting. With pixels you can look exactly like a game from whichever era you find most nostalgic, certainly with unique personal style, but the style is confined (with both benefits and detriment).