Yeah, but you could have the entire room as one texture instead of using tiles.
Generally I'm in favor of more generic light sources, and shadows as well since you can re-use the tiles.

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Also, you don't need to lose the outlines. It's a matter of style choice. But there is a point where it can be too much.

When you break up the outlines, you add more potential for depth and it adds variety.
So even if you plan on using a lot of outlines, it's still worth to learn how to avoid them, especially for small details where outlines would be too messy.

In the Layton example, there are a lot of outlines and it makes it looks quite crisp. But there are still places where they skipped outlines.
I guess that personally, I lean more towards a softer style.

[Edited]

I only brought it up because that's the style OP seems to be trying to mimic

I had fun with the last one so I made an edit for this one as well!
I can tell you've improved but you're still very fond of the black outlines
Don't forget to add more depth by highlights and shadows and offset things like the frame of the door so it looks more 3D.

Also, night time colors should be more exaggerated!
I figured light would come from the window, so I made flat surface that faces away from the window darker.
I also tried to add some highlights to get the effect of moonlight..

I notice a lot of you guys get really lighting-happy with graphics, but I think in the context of graphical assets that are supposed to be part of a game and not static scenes, when giving them a well-defined source of lighting, it means there needs to be edited versions of the same assets depending in which environment they are in.

Oh noes, what's under her bed?

Yeah, the pixeled signatures need to go and the small purple signature will probably be done by hand, to make it more genuine.

Thanks for the replies. Sounds like I'll just need to stop by my local print shop and sample a bunch of papers, pantones, etc.

You really should go to a professional print shop if you're serious about it, too. I remember going to staples to print stuff because I didn't have a large printer when I was in college and I had to teach them how to print my art  They didn't even know the difference between RGB and CMYK.

The first thing I thought of when I saw this was the little Professor Layton mini rpg on the last specter 

You seem to be thinking the same thing as me, that whatever I do, I should aim to get maximum color saturation and contrast. That seems to be the main element of the drawings.

It's obvious the only solution is to just compare how it looks on matte and gloss there's also semi-gloss paper.