I'm new to pixel art and started to make some 32x32 pixel art, but now I have to add some props and that's too big for it, would be ok to add 16x16 props or that would become a problem when you place objects into a game engine? will it be harder to snap to grids? (Unity, gamemaker..)

Sorry I know its a really newbie question I have tried searching for an answer but could not find it, so I hope someone here can help with it.

Thanks