You’re barely ten minutes into Squanch Games’ neon-soaked fever dream when you realize the talking guns aren’t the loudest things in the house. That honor belongs to Lizzie. In High on Life, the sister isn't just a background NPC or a plot device to be rescued; she’s basically the emotional (and often chaotic) anchor of the entire experience. While you're out there turning alien bounty targets into colorful goo, Lizzie is back at the house dealing with the literal displacement of her entire species. It’s a weird dynamic.
Honestly, the way the game handles the High on Life sister character is one of its most underrated features. Most games would have the family member screaming for help from a cage. Here? She’s trying to navigate a long-distance relationship with a blue alien named Tweeg while her house sits in the middle of Blim City. It’s messy. It's funny. Occasionally, it’s actually kind of heavy.
Who Exactly is Lizzie?
Lizzie is the protagonist’s older sister. When the G3 Cartel invades Earth to turn humanity into drugs—a sentence that still feels insane to type—she’s the one who stays with you. She’s voiced by Laura Silverman, who brings this perfect blend of "I’m over this" energy and genuine panic. If you recognize the voice, it’s probably because she’s a veteran of shows like The Sarah Silverman Program and Bob’s Burgers.
She represents the "normal" world that was stolen from you. While you’re becoming a lethal bounty hunter, she’s trying to maintain some semblance of a social life, even if that social life involves creatures that look like sentient trash bags.
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The Dynamics of the Household
The "High on Life sister" role changes as the game progresses. Early on, she’s just as confused as you are. But as the house gets warped to different planets, she starts taking up more space in the narrative. She interacts heavily with Gene Zaroothian, the washed-up, couch-surfing bounty hunter who lives in your living room. Their bickering is a highlight. Gene is cynical and gross; Lizzie is desperate for a life that doesn't involve alien guts on the carpet.
The Tweeg Situation: What Most People Miss
A huge chunk of the middle-game narrative revolves around Lizzie’s "boyfriend," Tweeg. It’s a subplot that some players find annoying, but it serves a real purpose. It shows how desperate people are for connection when their entire world has been deleted.
Tweeg is... sketchy. Even the Gatlians (your talking guns) think so. Kenny, the primary pistol voiced by Justin Roiland (or in the later High on Life updates, Alec Robbins), constantly warns you that something is off. The tension comes from whether you, as the player, should intervene or let her make her own mistakes.
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Why this matters for the story:
It forces the player to care about the house. Without Lizzie, the house is just a menu screen where you pick missions. With her, it's a home. When she eventually goes missing or gets into trouble, it feels personal because you've spent hours listening to her complain about the lack of Wi-Fi or her weird alien dating life.
Is the High on Life Sister Actually Likable?
This is a point of contention in the gaming community. If you browse Reddit or Steam forums, you’ll see a divide. Some players find her constant talking—and the drama with Tweeg—to be a distraction from the combat. They just want to shoot things.
Others argue she’s the most human part of the game.
Think about it. You’re a silent protagonist. You don’t say a word. The guns talk for you. Lizzie is the only person who treats you like a brother/sister rather than a killing machine. She calls you out. She worries. She’s the literal voice of the life you left behind on Earth. Without her, the game loses its stakes.
The Voice Acting Factor
Laura Silverman’s performance is key here. She nails the "disaffected millennial" tone perfectly. It fits the Squanch Games aesthetic—that mix of nihilism and slapstick humor. If she were played straight, like a typical "damsel," it wouldn't work. Because she’s sarcastic and occasionally "kinda" annoying, she feels like a real sibling.
Key Moments Involving Lizzie
There are a few specific points where the High on Life sister becomes the focal point of the gameplay loop.
- The Initial Invasion: She’s the one who pushes you to use the knife (Knifey) and actually get out of the house.
- The Tweeg Confrontation: This is a major turning point for her character development. She stops being a passive observer and starts taking agency.
- The Ending Sequence: No spoilers here, but her safety is a primary motivator for the final push against the G3.
How the Game Changed Post-Launch
There was a lot of talk about the "High on Life sister" dialogue frequency. Early players complained that the banter in the house was too much. In subsequent patches, the developers actually added settings to toggle the frequency of "Npc Chatter."
If you find her (or Gene) too chatty, you can actually go into the settings and turn it down. It’s a "quality of life" feature that specifically addresses the polarizing nature of the game’s writing style. But honestly? Turning it off kills the vibe. The chaos is the point.
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What Happened in the DLC?
In the High on Life: High on Knife DLC, the focus shifts a bit. While the main game was very much about the family unit, the DLC leans harder into the "horror-comedy" aesthetic with Knifey. However, the impact of the sister is still felt. The "High on Life" world is one where family is the only thing that isn't for sale, even if that family is driving you crazy.
Fact Check: Common Misconceptions
- Can Lizzie die? Without getting into heavy spoilers, the game follows a scripted narrative regarding her safety. You can't "accidentally" lose her through bad gameplay.
- Can you mute her? Yes, via the "Enemy/NPC Chatter" slider in the audio settings.
- Is she in every version? Yes, she is a core character on Xbox, PC, and PlayStation versions.
Actionable Takeaways for Your Playthrough
If you’re jumping into the game for the first time or doing a second run, pay attention to the TV in the living room when Lizzie is around. The game features full-length licensed movies (like Tammy and the T-Rex) that you can watch with her and Gene.
- Don't rush out of the house. Listen to the dialogue between Lizzie and Gene. It changes after every major bounty. It’s some of the best writing in the game and adds a lot of context to the world.
- Check her room. The environment tells a story. You can see how she’s trying to adapt to alien life through the items she collects.
- Interact with the guns while in the house. They often have specific comments about Lizzie’s current state of mind or her latest argument with Tweeg.
The sister is the heart of the game's weird, gross, vibrating world. She’s the reason you aren’t just a mercenary; you’re a survivor. Dealing with her drama is just as much a part of the "High on Life" experience as sticking a talking knife into an alien’s throat. It’s messy, it’s loud, and it’s exactly what makes the game stand out from every other shooter on the market.
Next Steps for Players:
To get the most out of Lizzie's character arc, make sure to return home immediately after the Douglas or Krubis bounties. Most players stay out in the hubs to explore, but the house dialogue triggers are time-sensitive. If you wait too long to go back, you might skip over some of the funniest bickering sessions between Lizzie and Gene regarding the "alien boyfriend" situation. Open your map, teleport back to the house, and just stand in the living room for five minutes. It’s worth the wait.