Weight loss has become a bit of a gold rush lately. You’ve probably seen the ads for GLP-1s, the injections, and the celebrity-endorsed "miracle" shots. But honestly, those aren't for everyone. They're expensive, sometimes hard to find, and not everyone is comfortable with needles. That’s where the Hers Medication Kit 3 comes into the picture. It’s a daily oral protocol designed for people who want a medical approach to weight management but maybe don't meet the criteria for—or just don't want—the injectable route.
Hers, the telehealth giant, isn't just handing out pills. They use a compounded approach. Kit 3 is specifically curated to target the psychological and physiological hurdles of losing weight, specifically food noise and cravings. It’s not a magic pill. It’s a tool.
What is Hers Medication Kit 3 anyway?
Basically, it's a combination of two specific medications: Bupropion and Naltrexone. If those sound familiar, it's because they are the same active ingredients found in the brand-name drug Contrave. However, Hers provides them as separate pills or in a specific compounded titration schedule.
Bupropion is an antidepressant that also happens to help with energy and focus. Naltrexone is an opioid antagonist usually used to treat alcohol or opioid dependence. Why put them together? Because when they team up, they hit the reward center of your brain. They tell that voice in your head that's screaming for a donut at 3:00 PM to just... be quiet.
It’s about "food noise." That’s the term everyone is using now to describe that constant mental chatter about your next meal. For many of us, the struggle isn't a lack of willpower; it's a brain chemistry that is constantly looking for a dopamine hit from sugar or fat. Kit 3 targets that loop.
The Science of the "Double-Punch"
The way this works is actually pretty cool. Bupropion increases levels of dopamine and norepinephrine in the brain. This helps stimulate neurons in the hypothalamus that signal you’re full. But, the body has a feedback loop that tries to shut that signaling down.
That’s where Naltrexone steps in.
Naltrexone blocks the receptors that try to dampen that fullness signal. By keeping the "I'm full" signal active for longer, the two drugs work synergistically. You eat less because you actually feel satisfied, and you crave less because the reward for eating junk isn't as intense as it used to be. Dr. Arwen Podesta, a board-certified psychiatrist and addiction specialist, has often noted how these mechanisms help bridge the gap between "knowing" you should eat better and actually "doing" it.
It's not just for "weight"
Hers often includes Vitamin B12 in these kits too. Why? Because when you start eating less, or when your body is adjusting to new medications, your energy can dip. B12 helps with metabolic function and keeps that "brain fog" at bay. It’s a smart addition that acknowledges the reality of a caloric deficit.
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Who is this really for?
I've talked to people who think any weight loss medication is a shortcut. It's not. Hers Medication Kit 3 is generally prescribed for women with a BMI over 30, or a BMI over 27 with a weight-related condition like high blood pressure.
It’s for the person who feels like their hunger is out of control.
If you’re someone who eats when you’re stressed, or someone who can’t stop at just one cookie, this is the type of metabolic support that makes sense. It isn't for the person looking to lose five pounds before a wedding. This is a long-term management strategy.
The side effects nobody likes to talk about
We have to be real here. You’re messing with your brain chemistry and your metabolism. You're going to feel it.
Nausea is the big one. Most people feel a bit "off" for the first week or two. It’s that sort of sea-sickness feeling that usually goes away as your body adjusts. Then there’s the constipation. When your digestion slows down or your habits change, things can get a bit backed up.
- Dry mouth: You'll be drinking a lot of water.
- Dizziness: Especially when you stand up too fast in the morning.
- Insomnia: Bupropion can be a bit "uppy," so if you take it too late in the day, you might be staring at the ceiling at midnight.
There are also more serious risks. Bupropion has a boxed warning regarding suicidal thoughts, especially in younger adults. And because it can lower the seizure threshold, anyone with an eating disorder like bulimia or a history of seizures should stay far away from Kit 3. This is why the medical consultation through the Hers platform is mandatory. You can't just "buy" it; a provider has to review your history.
What users get wrong about the process
One of the biggest misconceptions is that the medication does all the work. It doesn't. If you take Kit 3 and continue to eat ultra-processed foods and stay sedentary, you might lose a little weight initially, but you’ll hit a wall.
The medication gives you the headspace to make better choices.
It makes it easier to say "no" to the fries and "yes" to the salad because the fries aren't calling your name quite as loudly. Think of it like a crutch for a broken leg. The crutch helps you walk, but you still have to move your legs.
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The Cost: Is it actually worth it?
Hers operates on a subscription model. Usually, you’re looking at anywhere from $79 to $139 a month depending on how many months you prepay for.
Is it cheaper than Ozempic? Yes, by a lot.
Is it more expensive than a gym membership? Probably.
But for many, the cost is justified by the "all-in-one" nature of it. You get the medical consult, the shipping, and the meds in one price. You don't have to deal with insurance—which is a blessing because most insurance companies still treat weight loss meds like they’re a luxury item rather than a health necessity.
Actionable Steps for Success
If you’re considering starting the Hers Medication Kit 3, don't just jump in blindly. Success with this protocol requires a bit of planning.
Track your "Food Noise" before you start.
Spend three days jotting down every time you think about food when you aren't actually hungry. This gives you a baseline. When you start the medication, you'll be able to see if it's actually working on your brain, not just the scale.
Hydrate like it's your job.
Since dry mouth and constipation are the most common complaints, aim for at least 80-100 ounces of water a day. Add electrolytes if you’re feeling dizzy. This isn't just "health advice"; it’s side-effect management.
Take Bupropion in the morning.
To avoid the insomnia trap, get that first dose in as early as possible. Most providers recommend taking it with a small, non-fatty meal to help with the initial nausea.
Plan for a slow titration.
Don't rush the dose. If the provider says to start with half a tablet or one pill every other day, follow it. Pushing too fast is the fastest way to end up with a headache that lasts for three days.
Focus on protein.
As the medication suppresses your appetite, you’ll naturally eat less. You need to make sure what you do eat counts. Prioritize protein to maintain muscle mass while the fat comes off. Aim for 25-30 grams per meal.
The reality is that weight management is a marathon. Hers Medication Kit 3 is a solid option for those who need a psychological edge over their cravings, provided they are willing to put in the lifestyle work alongside the prescription.