So, you’re driving through Overland Park and you realize you forgot your prescription. Or maybe it’s 11:00 PM and you’ve got a sudden, desperate need for some cough medicine and a bag of Reese’s Cups. If you’re near the southern edge of town, you’re probably looking for the CVS at 127th and Antioch. It’s one of those neighborhood staples that everyone in Johnson County just sort of assumes has always been there, sitting right on that busy corner.
But here is the thing.
Navigation can be a total pain in this part of Kansas because everything looks like a clean, suburban grid until you’re actually trying to pull into a parking lot during rush hour. The CVS Pharmacy located at 12705 Antioch Rd, Overland Park, KS 66213 is tucked into a spot that serves a massive chunk of the community, from the students over at Blue Valley Northwest to the professionals heading home from the Sprint—well, now T-Mobile—campus area. It isn't just a place to grab a bottle of aspirin. It’s a logistical hub for the neighborhood.
Why this specific CVS location matters to Overland Park
Location is everything. If you live in the Windham Park or Nottingham St.Andrews area, this is your home base. Most people don’t realize that this specific intersection is a major gateway. Antioch Road is a literal lifeline for North-South travel in JoCo, and 127th Street (which turns into 127th Terrace depending on which way you blink) handles a staggering amount of local traffic heading toward the sports complexes or the highway.
I’ve spent plenty of time sitting at that red light.
The pharmacy here stays busy because it bridges the gap between the older developments and the newer, sprawling subdivisions further south. It’s also a stone’s throw from the Jack Stack Barbecue—which, honestly, if you’re picking up a prescription and you don’t smell that brisket in the air, you might have a cold. Seriously.
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Navigating the Pharmacy and MinuteClinic services
Most people come here for the pharmacy, obviously. It’s a high-volume location. One thing that’s kinda interesting about the CVS at 127th and Antioch is how they handle their drive-thru. It’s efficient, but if you show up at 5:15 PM on a Tuesday, be prepared to wait. Pro tip: use the CVS app to check if your script is actually ready before you pull into that line. There is nothing worse than waiting behind three cars only to find out your doctor hasn't called it in yet.
They also offer the standard suite of vaccinations. We’re talking:
- Annual flu shots
- COVID-19 boosters (when available and recommended)
- Shingles and pneumonia vaccines for the older crowd
- Tdap for the new parents in the neighborhood
Actually, the MinuteClinic services are what save people the most time. Instead of sitting in an urgent care waiting room for three hours because your kid has an ear infection, you can often book a slot here. It’s located inside the store, usually toward the back near the pharmacy counter. They handle the basic stuff—strep tests, minor rashes, and those "is this a cold or a sinus infection?" questions that plague us every October.
Store Hours and Weird Timing Issues
You’ve gotta be careful with the hours. While many CVS locations used to be 24-hour havens for night owls, many have shifted their schedules over the last few years due to staffing or corporate changes.
Generally, the front of the store stays open later than the pharmacy.
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Typically, the store opens around 7:00 AM or 8:00 AM and closes around 10:00 PM or midnight. The pharmacy, however, often closes its windows earlier—sometimes 7:00 PM or 8:00 PM on weekdays, and even earlier on weekends. Always, always check the specific hours for the day on the official website before you make the trek, especially on holidays like Labor Day or Christmas Eve.
What’s in the aisles at 127th and Antioch?
It’s a "Large Format" store. This means you aren't just getting the bare essentials. They have a decent grocery section. Look, no one is doing their full weekly grocery shopping at a CVS—unless you’re a college student or in a massive rush—but for milk, eggs, or a frozen pizza? It works.
They have a surprisingly robust beauty and cosmetic section. For some reason, this specific Overland Park location seems to keep the high-end drugstore brands in stock better than the ones further north near 95th street. Maybe it’s the demographic. Maybe it’s just better management. Either way, if you’re looking for a specific Maybelline shade or some La Roche-Posay skincare, this is a better bet than most.
- Photo Lab: They still do physical passport photos. It’s a lifesaver when you realize your passport expires in two months and you don't want to go to the post office.
- Greeting Cards: A massive aisle. Honestly, it’s probably the most-visited part of the store on Mother’s Day or Valentine’s Day.
- Seasonal Items: This CVS is ruthless with the seasons. You’ll see Halloween candy on the shelves in August and Christmas lights before you’ve even bought a turkey.
The "Overland Park Grid" and getting there safely
Driving to 127th and Antioch isn't hard, but the turn-ins can be tricky. If you’re heading South on Antioch, you want to make sure you’re in the right lane well before the 127th intersection. There are multiple entrances, but the one off 127th street is often easier to navigate than trying to turn directly off the main road when traffic is heavy.
People in Overland Park drive... let's call it "purposefully."
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It’s a high-income, high-traffic area. There are a lot of SUVs and a lot of people in a hurry. If you’re coming from the south (like from 135th street), it’s usually easier to take a left onto 127th and then enter the parking lot from the side. It beats trying to navigate the median on Antioch.
Common misconceptions about this location
I hear people say all the time that "all CVS stores are the same." They really aren't. The 127th and Antioch store is generally cleaner and better organized than the older urban locations. Because it’s in a newer part of the KC metro, the layout is wider. You don't feel like you're trapped in a cave of fluorescent lights.
Another thing: people think the MinuteClinic can do everything. It can't. If you’ve got a broken bone or something that requires an X-ray, don't go to 127th and Antioch. They’ll just tell you to go to the hospital down the road. They are great for "wellness" and "minor illness," but they aren't an ER. Know the difference before you waste your time.
Practical steps for your visit
If you’re planning a trip to this specific CVS, here’s how to make it suck less:
- Download the ExtraCare App: I know, another app. But seriously, the paper coupons at CVS are famously long—like, three feet long. The app just loads them onto your card so you don't look like a maniac at the register.
- Check the Pharmacy Lunch Break: Most CVS pharmacies now close for a 30-minute lunch break, usually between 1:30 PM and 2:00 PM. If you show up then, the gate will be down, and you’ll be stuck staring at a plastic wall while the pharmacist finally gets a bite to eat. Plan around it.
- Use the Drive-Thru for Pickups Only: Don’t be the person who tries to have a 10-minute consultation about their insurance co-pay in the drive-thru. If you have questions, go inside. The people in the cars behind you will thank you.
- Join CarePass if you’re a regular: If you live within two miles and get monthly prescriptions, the $5 a month usually pays for itself with the $10 monthly reward they give you. It’s basically free money if you’re already buying toothpaste there.
The CVS at 127th and Antioch is a cornerstone of the Overland Park community. Whether you’re grabbing a last-minute birthday card, getting your flu shot, or picking up a prescription after a long day, it’s a reliable spot in a busy part of town. Just watch the traffic, mind the pharmacy lunch hour, and maybe grab some of that Jack Stack BBQ across the street while you’re at it. You deserve it.
Check your prescription status via the automated phone system or the CVS mobile app before leaving your house to ensure the medication is in stock and ready for pickup. Verify the current closing time for the pharmacy department specifically, as it differs from the general store hours, especially on Sundays. If you require a vaccine, schedule an appointment online to skip the walk-in wait times which can exceed an hour during peak seasons.