Ever wake up and feel like you've missed a decade? That is basically the nightmare fuel fueling FOX’s new medical drama, Doc. It’s a total trip. The show, which kicked off in early 2025, centers on Dr. Amy Larsen. She was this high-flying, kinda terrifying Chief of Internal Medicine at Westside Hospital in Minneapolis. Then—boom—a car accident wipes out eight years of her memory.
Honestly, the Doc 2025 TV series characters are what make this show more than just another "medical procedural of the week." It isn't just about the surgeries. It’s about the messy, awkward, and sometimes heartbreaking reality of realizing you’ve become a person you don't even like.
The Woman at the Center: Dr. Amy Larsen
Molly Parker plays Amy, and she is incredible. Before the crash, Amy was a "hard-charging" doctor. That’s code for being a total shark who forgot how to have a bedside manner. But the Amy who wakes up? She thinks it's eight years ago.
She doesn’t know she’s divorced.
She doesn’t know her son died.
She’s basically a stranger in her own skin.
Watching Amy try to navigate a hospital where she used to be the boss—but now has to shadow residents like a student—is painful. Molly Parker brings this vulnerability that makes you root for her, even when you hear stories about how much of a jerk she used to be. It’s a second chance, but it comes with a massive bill.
The Support System (And the Complications)
Then you’ve got the people around her. It’s complicated.
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Dr. Michael Hamda (Omar Metwally): This guy is her ex-husband and the Chief Medical Officer. Imagine waking up thinking you’re happily married, only to find out you’ve been divorced for four years and your "soulmate" has moved on with a whole new life. Ouch.
Dr. Gina Walker (Amirah Vann): Amy’s best friend and a neuropsychiatrist. She’s the one trying to help Amy piece her brain back together. But Gina is in a tough spot. How much do you tell someone about their past if the truth might actually break them? She has to gatekeep Amy's own life.
The Secret Romance: Dr. Jake Heller
Jon-Michael Ecker plays Jake, and this is where the tea gets really salty. Before the accident, Amy and Jake were having a secret romance. She was his boss. Now? She has zero clue who he is.
Jake is still in love with her. He’s hurting, but he can’t exactly force her to remember a relationship she’s completely erased. It creates this simmering tension every time they’re in a room together. You can see it in his eyes, while she’s just trying to remember where the cafeteria is.
The Rivals and the Residents
Not everyone is happy Amy is back. Like, at all.
- Dr. Richard Miller (Scott Wolf): He took Amy’s job as Chief. He’s got some skeletons in his closet, specifically a medical mistake he’s trying to hide. For him, Amy’s memory loss isn't a tragedy—it's a lucky break. He’s waiting for her to fail.
- Dr. Sonya Maitra (Anya Banerjee): A third-year resident who hated the old Amy. Amy once told her she didn't have what it takes to be a doctor. Now, the tables have turned, and Sonya is the one supposed to be teaching Amy. It’s awkward. It’s petty. It’s great TV.
- Dr. TJ Coleman (Patrick Walker): A first-year resident who actually likes Amy. Turns out, she saved his life years ago and inspired him to go to med school. She doesn’t remember that either, but he’s one of the few people truly in her corner.
The New Blood in Season 2
If you've kept up with the 2026 updates, Felicity Huffman joined the cast as Dr. Joan Ridley. She’s the new Chief of Internal Medicine and acts as a mentor to Amy. She’s double-boarded in internal medicine and surgery, basically a total powerhouse. Her arrival shifted the dynamic of the hospital entirely, adding a layer of "old guard" wisdom to the chaos.
Why This Cast Works
Most medical shows focus on the "save of the day." Doc is different. It’s based on a true story (Dr. Pierdante Piccioni in Italy), so the stakes feel more grounded. The Doc 2025 TV series characters aren't just archetypes; they are people dealing with the "ghost" of who Amy used to be.
The show forces you to ask: if you lost the last eight years of your life, would you like the person you’d become?
What to Watch For Next
If you're just starting the series or catching up on Hulu/Disney+, pay attention to the background characters like Nurse Liz (Conni Miu) and Katie Hamda (Charlotte Fountain-Jardim), Amy’s daughter. The family dynamic is where the real tears happen.
Actionable Insights for Fans:
- Track the Time Jumps: The show uses flashbacks to show "Old Amy" vs. "New Amy." It helps to keep a mental note of the "Blue Tint" scenes which usually signify the past.
- Check the Source: If you love the US version, look up Doc - Nelle tue mani. It’s the Italian original and gives some clues about where the plot might go, though the US version has definitely blazed its own trail.
- Watch the Premiere Cycle: New episodes typically air Tuesdays on FOX. If you're watching in 2026, the second half of Season 2 is currently unfolding, so watch out for spoilers regarding Dr. Joan Ridley's true intentions at Westside.
The beauty of the show isn't in the medicine—it's in the memory. Or the lack of it.